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TMG (The Meta-Genome) is a high-level programming language designed for the manipulation and analysis of DNA and RNA sequences. It was developed by David J. Lipman and William R. Pearson in the early 1990s. TMG is a powerful tool for sequence analysis, allowing for the rapid development of new algorithms and the application of existing ones. It has been used to develop tools for sequence assembly, alignment, and analysis. TMG is also used for the analysis of proteins and other macromolecules. TMG is written in the C programming language and is available for download from the NCBI website.